Osteosarcoma is a malignant neoplasm derived from primitive cells (poorly differentiated cells) in the area metafise long bones. The classical osteosarcoma on plain image shows an aggressive lesion in the region metafise long bones. Damage to bone trabekule image with no clear boundary without endoosteal reaction. There also appears mixed area of ??radio-opaque and radio-lusen, by due process of bone destruction. Codman’s triangle, and the picture is accompanied by a picture Sunburst soft tissue mass, is the picture that is often encountered. In these patients seem osteodestruksi metadiaphysis radiologisnya examination the left femur with periosteal reaction mixture form (sun burst and amorphous) with soft tissue swelling.
Osteosarcoma is also called osteogenic sarcoma is a malignant neoplasm derived from primitive cells (poorly differentiated cells) in the area metafise long bones. Osteogenik called because of its development from primitive mesensim series osteoblastic cells. Osteosarcoma is a primary neoplasm of the bone is the commonest number after multiple myeloma.
Osteosarcoma usually found in long bones in which metaphysical growth plate (epiphyseal growth plate) is very active, ie at the distal femur, proximal tibia and fibula, proximal humerus and pelvis. In older people aged over 50 years, osteosarcoma can result from malignant degeneration of Paget’s disease, the prognosis is very poor.
The cause of osteosarcoma is still not clearly known. The existence of family relationships to be a predisposing, as well as the hereditery retinoblastoma and Fraumeni syndrome. It said some viruses can cause osteosarcoma in experimental animals. Ionizing radiation is said to be 3% of the direct causes of osteosarcoma, as well as alkyleting agent used in chemotherapy, and trauma can also cause the occurrence of this osteosarcoma.
Radiological Preview osteosarcoma is divided into 2 types, namely:
1. Form osteolytic (osteoklastic): tumors growing from the tip towards metaphisis diaphisis and little periosteal reaction and cortical destruction occurs. This form has no strict limit to the image of spicules and triangular codmann (codmann triangle). In codmann’s triangle is usually the case calcification and swelling.
2. Osteogenik form (osteoblastic): Overview of tumor appear more white with irregular borders. In this form of soft tissue calcification occurs so that the density increases, there is also a Sunray periosteal reaction or a sun burst. Sunray occurred prior to tumor metastases, in the form of thin lines (like light) is perpendicular to the axis of bone. Cortex into the soft tissues and cause soft tissue swelling. Sunburst is a bleak picture of the explosion of the sun.
The classical osteosarcoma on plain image shows an aggressive lesion in the region metafise long bones. Damage to bone trabekule picture with no clear boundary without endoosteal reaction. There also appears mixed area of ??radio-opaque and radio-lusen, by due process of bone destruction (bone destruction) and the process of bone formation (bone formation). Formation of new bone in the periosteum, cortical bone removal, with the formation of: Codman’s triangle, and the picture is accompanied by a picture Sunburst and soft tissue mass, is the picture that is often encountered.
Radiological examination of CT scans obtained in these patients appears osteo destruction metadiaphysis the left femur with periosteal reaction mixture form (sun burst and amorphous) and looks soft tissue swelling. So the patient including the form of osteosarcoma kedala Osteogenik.
Chemotherapy is a treatment that is very important in osteosarcoma, in 30 years with chemotherapy may facilitate limb salvage undergo a surgical procedure (limbsalvage procedure) and increase the survival rate of patients. Chemotherapy also reduced metastasis to the lungs and even there, easier to do the excision of these metastases. Perform surgery with resection of the tumor and do rekonstrusinya back and get a satisfactory function of ektermitas is one of the success in performing the operation. Amputation had to be done if surgery can not or do not allow anymore.
