Osteoarthritis is a chronic joint disease characterized by damage to joint cartilage and nearby bone, causing symptoms of pain and stiff joints. Biochemical disturbances occur in osteoarthritis bone fragility (hyalin). Formerly known as degenerative osteoarthritis, but later revealed that the joint fatigue, excessive use of joints and injury to the joints can cause damage to the joints and surrounding areas, causing osteoarthritis.

Normally the bones in the human joints are less likely to rub against each other because of joint fluid between the bones. Friction at the bone-joint cartilage and surrounding bone can occur when a joint is overused or when it happened trauma / injury to the joints. Joint fluid can also be reduced in certain conditions, such as the elderly, will decrease the production of joint fluid, vascular blood into the joints is also not as good as his youth.

Osteoarthritis begins with an abnormality in the formation of cells of joint cartilage, which is the collagen or proteoglycans that cause cartilage to grow too much, but thin and cracks formed on the surface of the cartilage. Small cavities were formed cartilage is taken and it is this which causes bones to become brittle. Over time the cartilage surface will be rough and porous so that the joints can not move smoothly. The bones in the joints will also experience an overgrowth of bone at the edges, giving rise to a lump of new bone, known as osteophytes. Bump this new bone cause pain and disrupt the function of joints.